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Health Encylopedia

 
Acetaminophen and codeine
 
SubjectContents
Definition This poisoning is from an overdose of acetaminophen with codeine.
Alternative Names Tylenol # 3
Poisonous Ingredient
  • Acetaminophen
  • Codeine
  • Where Found
  • Tylenol No. 3
  • Note: This list may not be all inclusive.
    Symptoms
  • Respiratory
  • Breathing slow and labored
  • (from the codeine)
  • Breathing shallow
  • (from the codeine)
  • Respiratory arrest (from the codeine)
  • Eyes, ears, nose, and throat
  • Pinpoint pupils (from the codeine)
  • Skin
  • Bluish skin
  • (fingernails and lips)
  • Gastrointestinal
  • Spasms
  • of the stomach and/or intestinal tract
  • Vomiting
  • Acetaminophen overdose over a certain toxic level leads to liver failure unless the antidote, N-Acetyl-cysteine, is given
  • Heart and blood vessels
  • Low blood pressure
  • (from the codeine)
  • Nervous system
  • Drowsiness
  • (from the codeine)
  • Home Treatment Seek emergency medical care immediately. Both Tylenol and codeine overdoses can be rapidly fatal. DO NOT INDUCE VOMITING .
    Before Calling Emergency Determine the following information:
  • The patient's age, weight, and condition
  • The name of the product (as well as the ingredients and strength, if known)
  • The time it was swallowed
  • The amount swallowed
  • If the medication was prescribed for the patient
  • Poison Control, or a local emergency number See Poison Control Centers for telephone numbers and addresses. Take the container with you to the emergency room.
    What to expect at the emergency room
  • For swallowed poison
  • Placement of a tube down the nose and into the stomach (a nasogastric tube, or an NG tube) to wash out the stomach (gastric lavage).
  • Activated charcoal administration.
  • Give IV fluids.
  • Admission to the hospital.
  • For Tylenol, N-Acetyl cysteine is given if the blood Tylenol level is high enough. Without the antidote, the patient has fatal liver failure.
  • Treat the symptoms.
  • Give a counteracting medication (narcotic antagonist). Multiple doses may be needed.
  • Expectations (prognosis) If an antidote can be given, recovery from an acute overdose often occurs within 24-48 hours.
      

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