| Subject | Contents |
| Definition | Poisoning from overdose of antidiarrheal agents containing diphenoxylate or atropine. |
| Alternative Names | |
| Poisonous Ingredient | diphenoxylate atropine |
| Where Found | Lomotil Diphenatol Lofene Logen Lomanate Lonox Lo-Trol Nor-Mil Note: This list may not be all inclusive. |
| Symptoms | respiratoryslow breathing eyes, ears, nose, and throat pinpoint pupils rapid side to side eye movement gastrointestinal constipation heart and blood vessels rapid heartbeat nervous system drowsiness loss of desire to do anything coma Note: Symptoms of toxicity may take up to 12 hours to appear |
| Home Treatment | The normal treatment is to induce emesis ( vomiting ) unless the patient is unconscious or experiencing convulsions ; however, before inducing emesis, contact Poison Control to verify that is the correct treatment. If instructed to induce emesis, proceed as follows or as otherwise instructed: Give the usual dose of ipecac syrup: 15 milliliters (ml) or 1 TABLEspoonful for children and 30 ml (2 TABLEspoonsful) for an adult. Follow with 1/2 glass or 4 ounces (oz.) of water for children or 8 to 12 oz. of water for adults. Repeat 1 more time in 1/2 hour if emesis has not occurred. |
| Before Calling Emergency | Determine the following information: the patient's age, weight, and condition the name of the product (ingredients and strengths if known) the time it was swallowed the amount swallowed if the medication was prescribed for the patient |
| Poison Control, or a local emergency number | They will instruct you if it is necessary to take the patient to the hospital. See Poison Control centers for telephone numbers and addresses. Take the container with you to the emergency room. |
| What to expect at the emergency room | Some or all of the following procedures may be performed: Induce emesis . Use gastric lavage . Administer activated charcoal. Administer a laxative. Administer a narcotic counteracting drug (antagonist) on a regular basis, approximately every 30 minutes. |
| Expectations (prognosis) | Fatalities can occur in children despite ipecac and charcoal therapy. Patients will normally recover with treatment and 24 hours of monitoring. |
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