| Subject | Contents |
| Definition | An inherited disorder characterized by mild jaundice throughout life. |
| Alternative Names | |
| Causes, incidence, and risk factors | Dubin-Johnson syndrome is inherited as an autosomal recessive disorder. The transport of bilirubin from the liver into the biliary system is abnormal and the bilirubin accumulates in the liver. Affected people have life-long low-grade jaundice which may be aggravated by alcohol, pregnancy , infection, and other environmental factors. |
| Symptoms | mild jaundice , may not appear until puberty or adulthood |
| Signs and tests | Tests which may be abnormal include: chem-20 to check bilirubin levels blood chemistry (may show sulfobromophthalein retention) Liver biopsy |
| Treatment | No specific treatment is available. |
| Support Groups | |
| Expectations (prognosis) | Dubin-Johnson syndrome is compatible with a normal life span. |
| Complications | Complications are unusual but may include: severe jaundice reduced liver function |
| Calling your health care provider | Call your health care provider if:jaundice is severe jaundice progressively worsens abdominal pain or other symptoms are also present (there may be another disorder causing the jaundice) |
| Prevention | Genetic counseling may be valuable for prospective parents with a family history of Dubin-Johnson syndrome. |
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